Global reference mapping of human transcription factor footprints

Global mapping of transcription factor motifs in human aging

Biological aging is a complex process dependent on the interplay of cell autonomous and tissue contextual changes which occur in response to cumulative molecular stress and manifest through adaptive transcriptional reprogramming. Here we describe a transcription factor (TF) meta-analysis of gene expression datasets accrued from 18 tissue sites collected at different biological ages and from 7 d...

Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer

  Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...

Mapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels

κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...

Mapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels

κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...

Human Footprints on the Global Environment: Threats to Sustainability